Unequal pupil size in cats11/13/2022 ![]() Coma or brain death: Severe brain damage may cause a change in the size and reactivity of the pupils. Anisocoria indicates a difference in pupil diameter in common clinical manifestations, if anisocoria is more marked in bright light, the large pupil is. Notice how this cats right pupil is much smaller (miotic) than the left pupil (mydriatic).Surgery: Eye surgery may result in alterations in pupil size, which can be permanent.Seizure: Sometimes seizures (a disruption of electrical activity in the brain) can cause changes in the pupils, which may be equal or unequal.Migraine: While it is not common, migraines can cause anisocoria.Vision loss: Significant vision defects can affect pupil size and reactivity. Simple anisocoria (otherwise known as physiologic or essential) is the most frequent cause of uneven pupil sizes.Increased intracranial pressure: This can result from a brain tumor, meningitis (inflammation of the fluid around the brain), or a stroke.Trauma: An injury affecting the eye or the brain may cause the pupils to be unequal.Inflammatory conditions, such as MS and sarcoidosis, also can do this. Inflammation: An infection affecting the eye or the cranial nerves can cause anisocoria.Cranial nerve damage: This can occur due to a stroke (a blockage of blood flow or bleeding in the brain), brain aneurysm (defect in a blood vessel), or a brain tumor.Multiple sclerosis (MS): MS is a chronic neurological disorder that causes symptoms affecting vision, movement, sensation, and more. ![]()
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